RETATRUTIDE
A weight management approach targeting three hormone receptors
- Point 1 : 01 A new approach targeting three receptors: GIP, GLP-1, and glucagon
- Point 2 : 02 Focuses not only on appetite control and blood sugar regulation, but also on energy metabolism
- Point 3 : 03 Designed as a once-weekly subcutaneous injection
Interpretation and counseling services are free of charge.
*Some doctors may require an additional fee for selection.
The Author
DR. YOKO MAEDA
Board-Certified Specialist, American Academy of Anti-Aging Medicine (A4M) / Director, Japan Society of Aesthetic Internal Medicine
A graduate of Hiroshima University School of Medicine, Dr. Maeda is a U.S. and Japan–certified specialist in aesthetic and regenerative medicine, offering advanced treatments such as hormone therapy and peptide therapy.She is known for her gentle, science-driven approach to natural beauty and continues to study the latest medical innovations with a passion for lifelong learning.
Our Approach at BIANCA CLINIC
Interest in retatrutide has grown as researchers explore its role in weight management and the multiple pathways involved in body weight regulation. Our physicians carefully review available international clinical data and current medical evidence before considering treatment for each client. We take the time to review your lifestyle, medical history, diet, and other relevant factors, considering not only your current health but also your long-term well-being.
We also provide a thorough explanation of the potential risks and limitations of treatment before you decide whether to proceed. Our priority is to ensure that you understand the treatment and feel comfortable with your decision while we support your journey toward health and beauty from within.
A consultation, in your own time
Online first visits are available. Our concierge supports international guests from arrival to departure.
Downtime
Bruising: Usually fades naturally within a few days
Makeup: Can be applied on the same day
Discomfort: A brief, mild pinprick may be felt during the injection
Treatment Time: A few minutes
Showering / Bathing: Allowed on the same day
During the initial stage of treatment, gastrointestinal side effects such as nausea, vomiting, diarrhea, constipation, and decreased appetite may occur. These symptoms often ease over time. If they are severe or persist, contact your physician.
Recommended for
- Those looking to reduce their daily food intake
- Those who want support with weight management beyond exercise alone
- Those looking to maintain their weight and reduce the likelihood of weight regain
- Those interested in trying a different approach to weight management
- Those who have noticed changes in their metabolism and want to take a broader approach to weight management
- Those looking for a structured treatment plan with fewer clinic visits
- Those looking to achieve healthy weight loss with support from a physician
Characteristics
Mounjaro (tirzepatide), which is also available at BIANCA CLINIC, is one example of the latter.
In contrast, retatrutide is a triple agonist that acts on three receptors—GLP-1, GIP, and glucagon. With this distinct mechanism of action, retatrutide is attracting attention as a new approach to medical weight management.
Together, these pathways allow retatrutide to target appetite, blood sugar control, and energy metabolism as part of a multi-pathway approach to weight management.
Treatment begins with a low dose, which is gradually adjusted under physician supervision based on your condition and response to treatment. At BIANCA CLINIC, we look beyond changes in body weight alone. We also monitor changes in your overall condition and daily lifestyle, supporting treatment at a pace tailored to your individual needs.
Benefits
Targets Both Appetite and Energy Metabolism
Dosing Adjusted to Your Individual Needs
Can Be Combined with Lifestyle Changes
Key Features
At your initial consultation, blood tests will also be performed to assess your health before treatment. Once treatment begins, we will regularly monitor changes in your overall condition and body weight.If you have any concerns or questions during treatment, please feel free to discuss them with your physician.
At BIANCA CLINIC, retatrutide treatment is combined with nutritional therapy and personalized lifestyle guidance. We also offer comprehensive wellness approaches tailored to each client's lifestyle and individual background, including epigenetic clock testing to assess biological age and orthomolecular nutritional therapy.
Rather than focusing only on short-term changes in weight, we support you in reviewing your daily habits with the goal of reducing the risk of weight regain and promoting long-term health and weight management.
A consultation, in your own time
Online first visits are available. Our concierge supports international guests from arrival to departure.
Treatment Area
Treatment Process
Consultation and Physician Assessment
Your physician will then assess your overall health, explain the characteristics of retatrutide, and determine whether the treatment is appropriate for you.
Blood Test (First Visit Only)
Treatment
At your first treatment, our medical staff will carefully explain how to use the pen, how to administer the injection, and the precautions to follow.
We will also provide guidance on nutrition and lifestyle habits to support you throughout your treatment.
Price List
RETATRUTIDE
| Dosage / Notes | PRICE | Notes |
|---|---|---|
| 4mg (Month 1) | ¥73,500/ tax incl. | Equivalent to 2.5 mg of Mounjaro |
| 8mg (Month 2) | ¥115,500/ tax incl. | Equivalent to 5 mg of Mounjaro |
| 16mg (Month 3) | ¥189,000/ tax incl. | Equivalent to 7-10 mg of Mounjaro |
・Consultation fee: ¥12,100 / tax incl.(for the initial prescription only).
・Blood test fee: ¥3,300/ tax incl. (for the initial visit only).
・Disinfection and needle fees are included.
・Blood tests are available Monday through Saturday only (not available on Sundays or public holidays).
Additional anesthesia and retouch within 2 weeks are included. Foreign currency estimates available on request. Pricing subject to change without notice.
Concept
Going beyond the realm of
cosmetic medicine,
we propose Lifestyle Beauty.
Our goal is to provide an experience that goes beyond mere satisfaction, a truly moving one.
Responding to the desire to “become more beautiful and healthy,”
what can we do for our patients’ happiness?
Providing total beauty that makes life shine—
That is our clinic’s policy.
BIANCA is a place where you can leave with a smile.
That’s the kind of place we aim to be.
FAQ
What is the difference between retatrutide and Mounjaro (tirzepatide)?
Mounjaro (tirzepatide) acts on two receptors, GIP and GLP-1, while retatrutide acts on three receptors: GIP, GLP-1, and glucagon. The difference in receptor targets does not make one treatment the better choice for everyone. Which option may be considered depends on the individual.
At BIANCA CLINIC, we carefully review your previous treatments, any symptoms you have experienced, and your current health before recommending an appropriate treatment approach for your individual needs.
How long does it take to notice changes with retatrutide?
There is no single timeline that applies to everyone. Clinical trials have reported changes over several weeks to several months of continued treatment.
At BIANCA CLINIC, we generally recommend continuing treatment for at least three to six months, even when considering a relatively short treatment period.
Your physician will monitor your progress and adjust the treatment plan based on your health, response, and lifestyle.
What are the side effects of retatrutide?
The most commonly reported side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, as well as decreased appetite and fatigue.
These symptoms are more likely to occur during the initial stage of treatment and may gradually improve over time.
If your symptoms are severe or persist, please contact your physician promptly rather than waiting for them to resolve on their own.
Is there any downtime after a retatrutide injection?
Because retatrutide is administered by injection rather than surgery, there is generally no downtime comparable to that associated with a surgical procedure. However, redness or swelling may occur at the injection site.
These symptoms often subside over time. If you experience persistent or concerning symptoms, please discuss them with your physician.
Can anyone receive retatrutide treatment?
No. Retatrutide treatment is not suitable for everyone. It cannot be provided during pregnancy or while breastfeeding. Depending on factors such as your BMI, medical history, and current medications, you may also be ineligible for treatment.
At BIANCA CLINIC, a physician will carefully assess your individual condition through a medical examination and blood tests before determining whether retatrutide treatment is appropriate for you.
Will I regain weight after stopping retatrutide?
Weight regain is possible after stopping treatment, particularly if previous lifestyle habits return.
This is why diet, exercise, and other lifestyle habits are worth addressing while treatment is still underway.
What should I keep in mind while receiving retatrutide treatment?
In addition to medication-based weight management, maintaining a balanced diet, getting appropriate exercise, and reviewing your overall lifestyle habits are important.
Throughout treatment, your physician will monitor changes in your condition and provide guidance as needed.
TREATMENT DETAILS
The treatment schedule may vary depending on your individual condition.
・The medication used for this treatment is imported through individual import procedures under the supervision and judgment of a physician. For more information, please refer to the Japanese Ministry of Health, Labour and Welfare’s guidance on medications requiring caution when imported for personal use:https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
・There are currently no medications approved in Japan that contain the same active ingredient.
・As of September 2026, retatrutide has not been approved in the United States or other major Western countries, and clinical trials evaluating its safety and efficacy are ongoing. Therefore, some serious risks may not yet have been fully identified.
・In the event of a serious adverse reaction, you may not be eligible for compensation under Japan’s Adverse Drug Reaction Relief System.
A consultation, in your own time
Online first visits are available. Our concierge supports international guests from arrival to departure.