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Pluryal

Pluryal

Pluryal is a regenerative injectable treatment that combines polynucleotides with advanced skin-repair technology to support hydration, collagen production, and overall skin quality.
  • Point 1 : 01 Supports skin repair and collagen production
  • Point 2 : 02 Helps improve redness, dryness, and fine lines
  • Point 3 : 03 Customized solutions for the face, under-eye area, and scalp

Interpretation and counseling services are free of charge.
*Some doctors may require an additional fee for selection.

SENHIME AKASHI

The Author

DR. SENHIME AKASHI

Board Certified Internist

A graduate of Nagoya University School of Medicine, Dr. Akashi is a certified specialist in internal medicine who has performed over 5,000 procedures in aesthetic surgery and aesthetic dermatology.
At BIANCA CLINIC, she integrates aesthetic surgery, dermatology, and regenerative medicine to enhance natural beauty from both inside and out.
She is fluent in Japanese, Chinese, and Korean, enabling her to stay at the forefront of global aesthetic trends.

Our Approach at BIANCA CLINIC

Pluryal product
KOL-Led Expertise in Regenerative Injectable Treatments
Rather than focusing solely on temporary correction, our approach emphasizes long-term skin quality and regenerative support. Pluryal is a biostimulatory injectable designed to support the skin's natural repair mechanisms by delivering polynucleotides directly into the dermis. Our clinic offers Pluryal Densify, Pluryal Silk, and Pluryal Hair Densify, allowing physicians to tailor treatment according to each patient's concerns, treatment area, and goals.

BIANCA CLINIC is also home to a Key Opinion Leader (KOL) involved in the field of regenerative injectables. This environment supports ongoing clinical education and technique refinement across our physician team. International patients can receive consultation and treatment support in English at our Ginza and Omotesando locations. If you are considering Pluryal during your stay in Tokyo, we welcome you to book a consultation to discuss a personalized treatment plan.

A consultation, in your own time

Online first visits are available. Our concierge supports international guests from arrival to departure.

Book a consultation → Chat on WhatsApp

Downtime

Following Pluryal treatment, temporary swelling, redness, injection marks, and mild bruising may occur. Small injection-site bumps are common immediately after treatment and usually settle within a few hours. Bruising or swelling, if present, generally improves within one to two weeks, although individual responses vary. A topical numbing cream is typically applied before treatment to improve comfort. Patients may wash their face on the same day while avoiding unnecessary friction. Makeup is generally recommended on the following day. Strenuous exercise, alcohol consumption, smoking, and heat exposure should be avoided immediately after treatment.

Recommended for

  • Fine lines around the eyes
  • Skin dryness and dehydration
  • Persistent facial redness
  • Uneven skin tone
  • Dull-looking skin
  • Reduced skin elasticity
  • Early signs of skin aging
  • Hair thinning or scalp quality concerns

CHARACTERISTICS

pluryal product
What Is Pluryal? Ingredients & How It Works
Pluryal is a regenerative injectable treatment that uses polynucleotides to support skin repair, hydration, and collagen production while improving overall skin quality. It is designed to support tissue repair, hydration, and collagen production while helping improve overall skin condition.

The technology behind Pluryal Polynucleotides, Pluryal PN, and Pluryal PDRN is based on highly purified polynucleotides derived from salmonid DNA. Once injected into the dermis, these nucleic acid fragments may support tissue regeneration processes by stimulating fibroblast activity, encouraging collagen synthesis, and helping modulate inflammatory responses. This regenerative mechanism differs from traditional fillers because the primary goal is skin quality improvement rather than volume replacement.

Pluryal treatment concept
Safety Profile & Side Effect Risk
The primary active ingredient in Pluryal is a highly purified polynucleotide with a favorable biocompatibility profile. Protein components are removed during manufacturing, which may help reduce allergy risk compared with less purified biological materials.
The Pluryal product line was developed by MD Skin Solutions in Luxembourg and is manufactured in accordance with European standards. The products have obtained CE certification, indicating conformity with applicable European regulatory requirements.

As with all injectable procedures, temporary redness, swelling, tenderness, bruising, and injection-site reactions may occur. Suitability should always be determined through physician consultation, particularly for individuals with fish allergies, autoimmune conditions, pregnancy, or breastfeeding status.

BENEFITS

Physician Expertise and Personalized Treatment Planning

Every Pluryal treatment begins with a thorough assessment of your skin quality, tissue condition, and aesthetic goals. Based on this evaluation, your physician selects the most appropriate formulation—whether Pluryal Densify, Pluryal Silk, or a scalp-focused option—and creates a customized injection plan.

Regenerative injectables rely on precise placement within living tissue. Thoughtful product selection and technique help support balanced, natural-looking results. A physician consultation is essential to determine the most suitable approach for your needs.

Comprehensive Skin Quality Improvement

Unlike treatments designed primarily to restore volume, Pluryal Skin Booster treatments focus on improving the overall condition of the skin itself. They may help address dehydration, fine lines, uneven skin tone, redness, and loss of elasticity.

Because the Pluryal range includes formulations for different treatment areas, concerns affecting the face, under-eye region, and scalp can be approached through a coordinated treatment plan tailored to the individual.

Biocompatible Regenerative Technology

Pluryal Polynucleotides are highly purified molecules developed to support tissue repair and regeneration. The purification process removes proteins associated with increased allergy risk, contributing to a favorable biocompatibility profile.

The Pluryal range is manufactured according to European standards and carries CE certification where applicable. As with any injectable treatment, suitability and potential risks should be reviewed during a physician consultation.

KEY FEATURES

Support for Redness, Dehydration, and Age-Related Skin Changes
Pluryal PN treatments are designed to support the skin's natural repair processes while improving hydration and overall skin quality. In addition to fine lines and loss of elasticity, Pluryal Densify may be considered for concerns such as visible redness, rosacea-prone skin, and chronic dryness.

Rather than focusing solely on volume enhancement, treatment is centered on improving the quality and resilience of the skin itself.
Specialized Formulations for Different Treatment Areas
The Pluryal portfolio includes multiple formulations designed for specific concerns and anatomical areas.
Pluryal Densify
commonly used for overall facial rejuvenation, redness, texture concerns, and skin quality improvement.
Pluryal Silk
developed for delicate areas such as the under-eye region and fine perioral lines
Pluryal Hair Densify
formulated to support scalp health and hair-density concerns
Following an assessment, your physician will recommend the formulation best suited to your anatomy, goals, and treatment priorities.
Built Around Progressive Improvement
Some patients notice visible improvements after a single treatment. However, regenerative treatments typically work best when performed as part of a structured treatment plan.

At BIANCA CLINIC, a 3-session package performed approximately every two weeks is commonly recommended for facial treatment. Depending on skin condition, lifestyle factors, and individual response, maintenance treatments may be considered every six to twelve months. This schedule can be particularly convenient for international patients who visit Tokyo periodically.

A consultation, in your own time

Online first visits are available. Our concierge supports international guests from arrival to departure.

Book a consultation → Chat on WhatsApp

Treatment Area

Face · Under-Eye Area · Perioral Area · Scalp (Pluryal Hair Densify)

Treatment Process

01

Physician Consultation

Physician Consultation
You will meet with a physician to discuss your concerns, medical history, and treatment goals. English-language support is available for international patients when needed. Based on your assessment, your physician will recommend the most appropriate Pluryal formulation and treatment plan.
02

Makeup Removal & Cleansing

Makeup Removal & Cleansing
Before treatment, makeup, sunscreen, and skincare products are removed. The treatment area is then thoroughly cleansed and prepared according to clinical protocols.

03

Numbing Cream (Optional)

Numbing Cream (Optional)
A topical numbing cream may be applied to improve comfort during treatment. Your physician will discuss comfort-management options based on the treatment area and your individual sensitivity.
04

Treatment

Your physician will perform the injections using a personalized treatment plan. Injection depth, placement, and product selection are adjusted according to your anatomy, skin condition, and treatment goals. Treatment typically takes around 20 minutes, depending on the area being treated.

Price List

Pluryal Densify

TREATMENT AREAAREA 1 session 3 sessions
Face ¥80,900/ tax incl. ¥231,000/ tax incl.
Additional Surface Anesthesia Fee: ¥3,630 / tax incl.

Pluryal Silk

TREATMENT AREA 1 session 3 sessions 6 sessions
Face ¥69,300/ tax incl. ¥187,200/ tax incl. ¥332,700/ tax incl.
Additional Surface Anesthesia Fee: ¥3,630 / tax incl.

Pluryal Hair Density

TREATMENT AREA 1 session 4 sessions 8 sessions
Head ¥69,300/ tax incl. ¥249,500/ tax incl. ¥443,600/ tax incl.

Options

PRODUCT PRICE
Exosome 1V ¥57,800/ tax incl.
Stem Cells 1V ¥57,800/ tax incl.

Additional anesthesia and retouch within 2 weeks are included. Foreign currency estimates available on request. Pricing subject to change without notice.

A consultation, in your own time

Online first visits are available. Our concierge supports international guests from arrival to departure.

Book a consultation → Chat on WhatsApp

Concept

BIANCA CLINIC

Going beyond the realm of
cosmetic medicine,
we propose Lifestyle Beauty.

Our goal is to provide an experience that goes beyond mere satisfaction, a truly moving one.

Responding to the desire to “become more beautiful and healthy,”
what can we do for our patients’ happiness?

Providing total beauty that makes life shine—
That is our clinic’s policy.

BIANCA is a place where you can leave with a smile.

That’s the kind of place we aim to be.

About Clinic

Q&A

Q

Is the Pluryal product used at BIANCA CLINIC the same as the product available internationally?

A

BIANCA CLINIC uses authentic Pluryal products supplied through appropriate medical distribution channels. Product availability may vary by country, but the formulations used are manufactured according to the manufacturer’s specifications.

Q

Can I request a same-day or short-notice appointment?

A

Same-day treatment may be available depending on physician schedules and treatment requirements. We recommend contacting the clinic as early as possible to confirm availability.

Q

Is one session of Pluryal worthwhile?

A

Yes, a single treatment session may provide visible improvements for some patients. However, a structured treatment plan often delivers more consistent and longer-lasting results. At BIANCA CLINIC, a 3-session package performed approximately two weeks apart is commonly recommended.

Q

Are there side effects associated with Pluryal

A

Temporary redness, swelling, tenderness, bruising, and small injection-site bumps may occur. These effects are generally mild and resolve gradually. As with any injectable procedure, risks and suitability should be discussed during consultation.

Q

What activities should I avoid after treatment?

A

Temporary aftercare restrictions are recommended. Patients should avoid strenuous exercise, alcohol consumption, smoking, excessive heat exposure, saunas, and hot springs immediately after treatment. Your physician will provide personalized aftercare instructions based on your treatment plan.

Q

Can I receive Pluryal treatment during a short trip to Tokyo?

A

Yes. Because downtime is generally limited, many international patients choose to undergo Pluryal treatment while visiting Tokyo. Treatment plans can often be coordinated around travel schedules, although individual recovery times vary.

Q

Can I continue treatment after returning home?

A

In many cases, yes. Your physician can discuss recommended treatment intervals and guide ongoing care. Availability of specific Pluryal products may vary by country and region.

Q

How long do results from Pluryal Skin Booster treatment last?

A

Results vary by individual. Many patients maintain improvements for approximately six to twelve months following their initial treatment series. Periodic maintenance sessions may help support ongoing skin quality improvements.

Treatment Details & Important Safety Information

Treatment Details
Pluryal is a regenerative injectable treatment containing polynucleotides that support skin repair, hydration, and collagen production through biostimulation. Depending on the formulation selected, treatment may be used for facial skin quality concerns, delicate under-eye areas, or scalp and hair-related concerns.
Estimated Treatment Duration & Sessions
Treatment typically requires approximately 20 minutes.

A treatment plan of three sessions performed approximately two weeks apart is commonly recommended. Maintenance treatment every six to twelve months may be considered depending on individual goals and skin condition.
Side Effects & Risks
Possible side effects and risks include:

・Redness
・Swelling
・Tenderness
・Injection-site bumps
・Bruising
・Temporary discomfort
・Allergic reactions
・Infection
・Asymmetry
・Unsatisfactory aesthetic outcome

Results vary by individual.
Contraindications
Treatment may not be suitable for individuals who:

・Have fish or fish roe allergies
・Are pregnant or breastfeeding
・Have autoimmune diseases
・Have a history of hypersensitivity to treatment components

Suitability must be determined through physician consultation.
Use of Unapproved Medical Devices & Pharmaceuticals
Some Pluryal products used in aesthetic medicine may not be approved by Japanese regulatory authorities or may be used outside approved indications in Japan.

These products are imported individually under the responsibility and clinical judgment of the supervising physician.

Reference:
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html

No equivalent domestically approved product may be available for certain indications.

The Pluryal product line was developed by MD Skin Solutions in Luxembourg and has obtained CE certification in Europe.

Treatments using imported pharmaceuticals are not covered by Japan's Adverse Drug Reaction Relief Fund.
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