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The Author

DR. YUKITARO IKEDA

  • Certified Occupational Physician by the Japan Medical Association

Dr. Yukitaro graduated from Kumamoto University School of Medicine in 2019. After training in general and emergency medicine, he transitioned to the aesthetic field in 2022, where he served as a director at a leading cosmetic clinic. He joined BIANCA CLINIC in 2024.He specializes in providing comprehensive treatments that combine aesthetic surgery with internal and dermatological medicine. He is known for performing advanced international procedures like the FOX EYE LIFT and Barbie Botox, and his expertise also includes double eyelid surgery and men's aesthetic treatments.Fluent in both Japanese and English, Dr. Yukitaro is also a Key Opinion Leader (KOL) for several aesthetic brands, and is dedicated to offering inclusive, high-quality care to patients of all backgrounds.

Professional ezGEL injection procedure at BIANCA CLINIC for facial rejuvenation.

More and more residents and international patients are choosing ezGEL nasolabial folds treatment as a way of rejuvenating their appearance. This approach softens deep creases beside the nose and mouth while keeping expression and facial identity using a gel created from your own plasma.
Nasolabial folds deepen with age as the tissues that support the skin gradually lose volume and skin laxity. There’s only so much makeup can do, and many people prefer to avoid synthetic fillers. ezGEL nasolabial fold injections offer a middle path: noticeable yet soft improvement that feels natural.
In this article we explain what ezGEL nasolabial fold injections are, how it works, who benefits, how it compares with similar treatments, and what to expect at BIANCA CLINIC, a conveniently located, “near me” aesthetic clinic with a highly proficient English-speaking beauty clinic team in central Tokyo.

What is ezGEL for Nasolabial Folds?

ezGEL is an autologous (made from your own tissues) filler. In fact, it is derived from your own circulating blood. A small sample of blood is processed in the clinic to separate platelet-rich components and heat-modified plasma proteins (mainly albumin). The result is a smooth, injectable gel that can gently fill and hydrate the nasolabial area while supporting healthy skin function.

ezGEL Nasolabial FoldsKey Features

ezGel nasolabial folds are a smooth, moldable gel made entirely from your own blood plasma, and designed for a soft, natural appearance of smile lines. The fact that it is autologous means that there is minimal risk of allergic reactions. Growth factors from platelet-rich components of the gel help support gradual skin quality improvement and the gel is then prepared in the clinic and its characteristics (e.g. viscosity, volume) are calculated for your particular anatomy.

ezGEL Nasolabial Folds Benefits of Treatment

The benefits of ezGEL nasolabial folds among other cosmetic surgery treatments include, a natural appearance and feel to the skin with fully preserved facial movements and a very low risk of skin sensitivity as the gel is derived from your own tissue. The treatment requires a short appointment with minimal time off compared with other treatments. Initial clinical experience and small prospective studies report high patient satisfaction in the months after treatment. As with any emerging techniques, outcomes depend on careful assessment, high standards of gel quality, and an experienced injector.

How Does ezGEL Nasolabial Folds Treatment Compare to Other Therapeutic Options?

ezGEL nasolabial folds cosmetic surgery treatment offers soft, subtle volumizing, typically lasting 6–9 months and commonly costs 60,000–150,000 JPY per session in Tokyo. As ezGEL is an autologous filler it is not enzyme-dissolvable but naturally instead, naturally resorbs over time.
Hyaluronic acid (HA) fillers can lift more strongly, and typically last 9-18 months. They usually cost in the region of 60,000–120,000 JPY per syringe in Tokyo and can be dissolved with hyaluronidase. Poly-L-lactic acid (PLLA)(Sculptra) treatment stimulates collagen in the skin, gradually lasting 18–24 months and costing 80,000–120,000 JPY per vial. Fat transfer adds greater volume and can be long lasting although this is variable. It costs 300,000–600,000+ JPY per vial and involves 1–2 weeks for harvesting the fat.
All treatments are well tolerated with numbing. ezGEL, HA and PLLA usually bring mild swelling or bruising for 2–5 days. Other risks associated with these treatments include asymmetry, and rare vascular events (that are possible with any injection).

BIANCA CLINIC in Tokyo: Our Clinical Pathway

BIANCA CLINIC is in a convenient “near me” location with easy access in central Tokyo. We have clear and well-established pathways to subtly enhance your appearance in a variety of ways. Here’s what our clinical pathway looks like:

Before your visit

You will discuss your goals, medical history, and the pros and cons of alternative options. With our specialist English-speaking health professionals. You will show us the medications you have been using (eg. blood thinners) and any supplements as these may need temporarily stopping prior to your ezGEL nasolabial folds treatment.

On the day of your treatment

You will arrive with clean skin, and we will take discreet before and after photos to document your progress. You will provide us with your informed consent, then one of your chosen practitioners will map the skin folds carefully. A small sample of blood is drawn (typically 10–20 mL). Plasma is centrifuged and thermally processed into gel, then prepared for injection. We apply numbing cream to the area using a fine cannula, and the gel is placed precisely along the folds and gently shaped. The total time for the procedure is about 45–60 minutes, including preparation. You can return to light activities the same day.

Aftercare

You can expect mild swelling or tenderness for 2–3 days and small bruises that can last up to a week. We advise you to avoid heavy exercise, saunas, and alcohol for 24–48 hours. Keep the area clean and avoid pressing. After 6 hours, makeup may be applied but you should sleep on your back the first night if possible. At your follow-up appointment in 2–4 weeks we will assess your progress.

Who is a Good Candidate for ezGEL Nasolabial Folds?

You would be suitable for this treatment if you have mild to moderate nasolabial folds and are seeking natural, biocompatible softening. This treatment is also suitable for those who prefer natural autologous products to synthetic fillers with results that appear gradually over time.

ezGEL Nasolabial Folds FAQs

Q. How long do ezGEL nasolabial folds results last?

Many people notice visible improvement for about 6–9 months, depending on individual factors like metabolism, fold depth, and lifestyle.

Q. Are ezGEL nasolabial folds safe?

Yes. It is prepared from your own plasma, hence a very low risk of allergy. As with any injection, choose a skilled injector to minimize complications.

Q. Can ezGEL be dissolved?

No. Being an autologous product, enzymes are unable to dissolve it, but it naturally resorbs over time. If reversibility is a priority, an HA filler may suit you better.

Q. Do ezGEL nasolabial folds hurt?

Mild discomfort is only to be expected as the procedure is performed with topical numbing and a gentle cannula technique.

Q. Can I combine ezGEL with other treatments?

Yes. Some treatment plans include ezGEL with HA for lift, with PLLA for collagen stimulation, or with energy devices for skin tightening, spaced appropriately.

Q. Who Should Avoid ezGEL Nasolabial Folds Treatment?

This treatment is not advised for pregnant women or women who are breastfeeding, and any patient with active infection, severe bleeding disorders, or uncontrolled autoimmune disease

Ready for ezGEL Nasolabial Folds?

Overall, ezGEL offers a gentle, autologous way to soften nasolabial folds with minimal downtime and a natural finish. If you want expert guidance at a Tokyo aesthetic clinic with clear English support, BIANCA CLINIC is ready to help. Contact us to request a free consultation to explore a personalized plan that suits your needs.