Dermal Fibroblast Therapy
Interpretation and counseling services are free of charge.
*Some doctors may require an additional fee for selection.
Price List
Treatment Area
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Face, neck, and hands. Fibroblasts are extracted from behind the ear.
Dermal Fibroblast Therapy
Interpretation and counseling services are free of charge.
*Some doctors may require an additional fee for selection.
Recommended for
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Want to reduce wrinkles around the eyes or mouth
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Want to improve facial sagging
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Are concerned about acne scars
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Are worried about aging signs on the neck or hands
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Are seeking a naturally youthful look
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Are hesitant about injecting external substances
RESULTS
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1.JAPAN QUALITY
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1.JAPAN QUALITY
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1.JAPAN QUALITY
This is an examplethis is an example this is an ex
Read more -
1.JAPAN QUALITY
This is an examplethis is an example this is an ex
Read more -
1.JAPAN QUALITY
This is an examplethis is an example this is an ex
Read more -
1.JAPAN QUALITY
This is an examplethis is an example this is an ex
Read more -
1.JAPAN QUALITY
This is an examplethis is an example this is an ex
Read more -
1.JAPAN QUALITY
This is an examplethis is an example this is an ex
Read more
FEATURES
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What is Dermal Fibroblast Therapy?
Dermal fibroblast therapy is a regenerative treatment that involves extracting fibroblasts—the skin cells responsible for producing collagen, elastin, and hyaluronic acid—from behind the ear, culturing and expanding them in a fibroblast culture medium, and injecting them into areas of concern. Fibroblasts begin to decrease after age 20, with about two-thirds gone by age 50. Injecting these cultured dermal fibroblasts into wrinkled or sagging areas is expected to help improve skin function and alleviate concerns[1].
Cultured skin cells can be increased to 40 million to 100 million cells and stored semi-permanently. Harvesting cells while still young allows you to address skin concerns years or even decades later. -
Slowing Down Skin Aging with Fibroblast Therapy
Due to aging and stress, skin cells decrease and deteriorate over time. Dermal fibroblast therapy introduces activated skin cells into skin losing firmness, promoting healthy skin function. The fibroblasts produce dermal collagen, elastin, and hyaluronic acid, offering improvements in sagging and wrinkles. Regular treatments have the potential to noticeably slow skin aging, making this an exciting new option for anti-aging.
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Results Appear Around 3 Months After Treatment
The process from pre-treatment to the appearance of results with dermal fibroblast therapy is as follows:
[Before Treatment] Skin showing signs of aging
As we age, the number of skin cells decreases and their function declines. The dermis becomes thin and fragile, which is a primary cause of aging symptoms such as wrinkles and sagging.
[During Treatment] Transplantation of cultured dermal fibroblasts.
Healthy skin cells, cultured from a skin sample into 40 to 100 million cells, are transplanted into the areas of concern. These cells support tissue repair by producing dermal collagen, hyaluronic acid, and elastin.
[Around 3 Months After Treatment] Visible changes in the skin.
As new dermal collagen, hyaluronic acid, and elastin accumulate within the skin, symptoms such as wrinkles and sagging are reduced. The skin’s firmness and elasticity are expected to improve. While individual results may vary, some patients report noticeably more youthful skin around 3 to 12 months post-treatment.
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Downtime after Dermal Fibroblast Therapy
Washing your face, applying makeup, and bathing: Permitted from the following day.
※ Swelling, redness, or bruising may occur but typically subsides within 1 to 2 weeks. In rare cases, small lumps may form.
※ It may take about 1 to 6 months for the transplanted skin cells to settle and begin repairing the skin tissue.
※ If you are taking anticoagulants or antihistamines, please inform your doctor in advance.
Dermal Fibroblast Therapy
Treatment Benefits
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Natural and Long-Lasting Effects
As this is regenerative medicine using your own vigorous skin cells, the results last longer than other injection treatments and provide a natural appearance.
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Slows Down Skin Aging with Regular Treatments
Ongoing treatments help delay aging compared to untreated skin, aiding in maintaining youthful firmness.
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Minimal Downtime
You can wear makeup and bathe the day after treatment. Using your own cultured dermal fibroblasts minimizes allergic risk and bodily stress.
TREATMENT PROCESS
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Consultation with Doctor
Discuss your concerns and symptoms. The doctor will answer all your questions thoroughly.
Discuss your concerns and symptoms. The doctor will answer all your questions thoroughly.
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Blood & Skin Sampling
To culture the cells, a small piece of skin about the size of a grain of rice is collected from behind the ear. In addition, a blood sample is taken to be used as the culture medium (the environment needed to grow the skin cells). The cultured cells are meticulously managed by specialized technicians at the cell culture center and are expanded approximately 10,000 times over the course of about five weeks. Any cultured cells not used for immediate transplantation can be cryopreserved at a specialized facility for future use.
To culture the cells, a small piece of skin about the size of a grain of rice is collected from behind the ear. In addition, a blood sample is taken to be used as the culture medium (the environment needed to grow the skin cells). The cultured cells are meticulously managed by specialized technicians at the cell culture center and are expanded approximately 10,000 times over the course of about five weeks. Any cultured cells not used for immediate transplantation can be cryopreserved at a specialized facility for future use.
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First Cell Transplant
This occurs between 5 weeks and 3 months after the skin is collected.
This occurs between 5 weeks and 3 months after the skin is collected.
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Second Cell Transplant
The second transplant is recommended within approximately two weeks after the first. Performing the second transplantation within a short interval increases the likelihood of successful cell engraftment.
The second transplant is recommended within approximately two weeks after the first. Performing the second transplantation within a short interval increases the likelihood of successful cell engraftment.
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Third & Future Transplants
Since the cryopreserved skin cells can be stored semi-permanently at a specialized facility, any subsequent transplants—such as a third session—can be scheduled at your discretion, even 1 to 2 years later. As a form of regular maintenance therapy, you can receive transplants of the youthful skin cells harvested at the time of collection over the span of several years or even decades. (The volume of stored skin cells depends on the selected treatment plan.)
Since the cryopreserved skin cells can be stored semi-permanently at a specialized facility, any subsequent transplants—such as a third session—can be scheduled at your discretion, even 1 to 2 years later. As a form of regular maintenance therapy, you can receive transplants of the youthful skin cells harvested at the time of collection over the span of several years or even decades. (The volume of stored skin cells depends on the selected treatment plan.)
PRICE LIST
View the price list for Dermal Fibroblast Therapy
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Dermal Fibroblast Therapy
40 Million Cells Plan [Includes] Blood test fee, Skin harvesting and cell extraction for 600 million cells (60cc) Two transplantation sessions using 40 million cells (4cc) Procedure fees for both sessions. ¥1,760,000（tax inc.） 80 Million Cells Plan [Includes] Blood test fee Skin harvesting and cell extraction for 600 million cells (60cc) Two transplantation sessions using 80 million cells (8cc) Procedure fees for both sessions. ¥2,640,000（tax inc.） 100 Million Cells Plan [Includes] Blood test fee Skin harvesting and cell extraction for 600 million cells (60cc) Two transplantation sessions using 100 million cells (10cc) Procedure fees for both sessions ¥3,080,000（tax inc.） -
Fees for Additional Transplant Sessions (3rd session and beyond)
Transplanted Cells 2cc ¥275,000（tax inc.） Transplanted Cells 4cc ¥550,000（tax inc.） Transplanted Cells 8cc ¥1,100,000（tax inc.） Transplanted Cells 10cc ¥1,375,000（tax inc.） Monthly Cell Storage Fee ¥11,000（tax inc.） Additional procedure fee applies ¥110,000 per session（tax inc.）
FAQ
- Q Who is dermal fibroblast therapy recommended for?
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A
Dermal fibroblast therapy is a regenerative skin treatment ideal for those who want to restore a naturally youthful appearance using their own skin cells, and for those seeking long-lasting results from a single injection session. If you’re interested, we encourage you to schedule a consultation.
- Q Why is the skin sample taken from behind the ear?
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A
The skin behind the ear is less exposed to ultraviolet rays and friction, and is therefore less affected by aging compared to other areas. To extract the youngest and least damaged skin cells possible, we collect skin samples from this location.
- Q What is the treatment schedule like for dermal fibroblast therapy?
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A
Since culturing the cells takes time, the first transplant is performed approximately 5 weeks after skin sampling. To help ensure a higher rate of cell engraftment, the second injection is recommended within two weeks of the first. Full details will be explained during your consultation.
- Q Are there any side effects with dermal fibroblast therapy?
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A
Because the therapy uses your own skin cells, the risk of side effects is minimal and the treatment is designed to be gentle on the body. However, since a needle is used during injection, temporary swelling, redness, or bruising may occur, typically resolving within 1–2 weeks.
- Q How is this different from hyaluronic acid or Botox injections?
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A
Unlike hyaluronic acid or Botox, which add volume or suppress muscle movement, dermal fibroblast therapy takes a more fundamental approach by increasing the actual skin cells responsible for moisture and elasticity. It tends to offer longer-lasting improvements.
- Q Is it better to harvest fibroblasts at a younger age?
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A
There is no age restriction for fibroblast harvesting—you can start at any age. In fact, those with more advanced signs of aging may notice more visible improvements after treatment.
- Q What exactly are dermal fibroblasts?
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A
Dermal fibroblasts are cells found in the dermal layer of the skin and are responsible for producing dermal collagen, elastin, and hyaluronic acid. When fibroblasts are abundant, the skin maintains firmness and moisture. However, their numbers decline sharply after age 50. Dermal fibroblast therapy increases the number of these cells, making it an effective option for aging skin.
- Q Is dermal fibroblast therapy covered by insurance?
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A
No, dermal fibroblast therapy is a self-funded (private) treatment and is not covered by insurance. Because the skin cells are managed under strict supervision at a cell culture center 24 hours a day, the cost is relatively high. However, at BIANCA CLINIC, we offer a variety of other skin treatment options as well, so feel free to consult us regarding your aging concerns.