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The Author

DR. SUMI MINAMI

  • Board Certified Cosmetic Surgeon

A well-rounded physician engaged in treatment from both aesthetic dermatology and cosmetic surgery perspectives, with "doing what is best for the patient" as the top priority, dedicated to pursuing natural and refined beauty. Also a member of the Japan Society of Aesthetic Surgery (JSAS). Specializing in hyaluronic acid injections, thread lifts, and facial contouring surgery, and serving as a KOL (Key Opinion Leader) for ARTEMIS LIFT, Hydro, and Rejuran. A highly skilled practitioner who remains constantly attuned to the latest trends while continually deepening knowledge and refining technique.

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We have newly introduced the SKINPLUS collagen booster, a next-generation human-derived skin booster designed to support skin quality from within. By addressing the foundation of the skin with an advanced multi-component formulation, it aims to help improve smoothness and overall skin condition.

SKINPLUS Key Points

  • Supports skin reconstruction to improve overall skin quality
  • Designed with human-derived components, with consideration for allergy risk
  • Advanced manufacturing technology helps reduce discomfort and downtime.

SKINPLUS at BIANCA CLINIC: Advanced Techniques from a Pioneer in Aesthetic Medicine

CELLDIEM (SKINPLUS) is a skin booster developed in Korea. At BIANCA CLINIC, we continuously explore innovative treatments from both Japan and overseas. However, we only introduce procedures after carefully evaluating whether they are truly beneficial and whether they meet the needs of our patients.

Among the many skin boosters available, CELLDIEM (SKINPLUS) has shown strong potential for various skin types, which led to its introduction at our clinic.
Our clinic is an aesthetic medical facility that provides high-quality treatments as a Skinplus medspa, where physicians with extensive knowledge of skin boosters and advanced injection techniques perform the procedures.

With injectable treatments, the final outcome can vary significantly depending on the injection depth, volume, and placement. That is why we customize every treatment—adjusting depth and dosage according to each individual’s skin condition and goals. Our aim is to deliver high-quality results that feel truly “ideal” to you.

Downtime

Redness, swelling, pain, or bruising may occur. Bruising typically subsides within a few days to about two weeks, though individual differences may apply.

SKINPLUS Recommended For

  • Those concerned about dryness or tightness
  • Those who want to restore firmness and radiance
  • Those looking to improve uneven skin texture
  • Those struggling with poor makeup adherence or makeup breakdown
  • Those seeking treatment for multiple skin concerns
  • Those seeking fundamental skin quality improvement through SKINPLUS treatment

SKINPLUS Characteristics

SKINPLUS |Trust BIANCA in Tokyo, Japan tailored to your love handles. love handles BIANCA in Tokyo, Japan

What Is CELLDIEM (SKINPLUS)?

CELLDIEM (SKINPLUS) is a Korean-developed skin booster designed to improve the overall condition of the skin. It addresses a wide range of concerns, including fine lines, loss of firmness and glow, and uneven texture.

Typically, different skin concerns require separate treatments. However, with CELLDIEM (SKINPLUS), a single procedure may help reduce the appearance of fine lines while enhancing radiance, tone clarity, and overall skin quality. It is also designed with consideration for minimizing the risk of immune reactions, inflammation, and allergies.

In Korea, the product is known as CELLDIEM, while in Japan it is referred to as SKINPLUS aesthetics, reflecting its aesthetic medicine applications.

Supporting Skin Structure with Human-Derived ECM Components

CELLDIEM (SKINPLUS) contains multiple key components such as collagen, elastin, and GAGs (glycosaminoglycans), allowing it to approach the skin on multiple structural levels. These ingredients are classified as human-derived ECM (extracellular matrix) components, extracted from human tissue.

By closely mimicking the skin’s natural structural elements, the treatment supports skin reconstruction from within. Over time after the procedure, patients may notice not only improved hydration, but also enhanced skin density and elasticity.

Because the formulation is human-derived, it is considered highly biocompatible and designed with attention to minimizing allergy risk. For those interested in seeing actual treatment outcomes, SKINPLUS dermatology photos are available to view at our clinic.

Micro-Particle Technology for Deep, Even Delivery

CELLDIEM (SKINPLUS) features ultra-fine particles measuring 75 μm. The small particle size contributes to reduced discomfort during treatment.
These micro-particles naturally disperse within the skin tissue, allowing beneficial components such as collagen to be delivered evenly and stably into deeper layers of the skin. Lumps and post-treatment swelling are less likely to occur, and downtime is generally considered minimal.

SKINPLUS Merits

A Unique Formulation That Addresses Multiple Concerns

Essential skin components, including collagen, are combined in a proprietary formulation. A single treatment can address multiple concerns such as pigmentation, freckles, reduced firmness and radiance, and lack of elasticity.

Designed with Consideration for Immune and Allergy Reactions

As a human-derived formulation, cellular components that may trigger immune reactions have been removed. The design takes potential immune and allergic responses into account.

Improves Skin Quality for Longer-Lasting Results

By incorporating components that form the structure of the skin, CELLDIEM (SKINPLUS) supports reconstruction and overall skin quality improvement. When the skin’s foundation is strengthened, healthy-looking results are more likely to last.

SKINPLUS What to Know

How the Effects Appear

Because CELLDIEM (SKINPLUS) can address multiple concerns, there is no need to undergo numerous separate treatments. However, as a skin booster, immediate dramatic results are not guaranteed. Instead, think of it as gradually “nurturing” and strengthening your skin over time.

The way results appear varies by concern and individual. Some patients notice improvements across multiple areas after a single session, while others observe gradual improvements—first in one concern, then another—with repeated treatments.

During the treatment planning stage, we estimate how results may develop. In practice, we flexibly adjust the approach based on how your skin responds after each session, providing a truly personalized treatment plan tailored just for you.

After treatment, temporary redness, swelling, pain, or bruising may occur. Bruising often subsides within several days to two weeks, although the duration may vary depending on the individual.

CELLDIEM (SKINPLUS) or Another Skin Booster?

CELLDIEM (SKINPLUS) is often referred to as a fifth-generation skin booster. Rather than simply replenishing moisture at the surface, it aims to improve overall skin quality. It is frequently chosen by those concerned about dullness, fine lines, and uneven texture.

At our clinic, we offer several types of skin boosters. Among them, CELLDIEM (SKINPLUS) is particularly recommended for those seeking not only firmness and elasticity, but also smoother, more refined, and evenly toned skin.

Depending on your skin condition and concerns, we can also provide comparisons and recommendations among different skin boosters.

Strict Quality Control for Greater Peace of Mind

CELLDIEM (SKINPLUS) is formulated using human-derived components, with careful attention to material characteristics. In general, human-derived ingredients are considered highly biocompatible and designed with allergy risk in mind.

During the manufacturing process, cellular components and nucleic acids (DNA and RNA) that may potentially trigger immune responses are removed. In addition, post-processing tissue undergoes external evaluation to confirm compatibility with cells.

Through these rigorous steps, CELLDIEM (SKINPLUS) has been developed with safety considerations at the forefront, making it one of the skin booster options patients can consider with confidence.

Celdiem (SKINPLUS) Treatment Areas

  • Full face

Celdiem (SKINPLUS) Treatment Process

Consultation & Medical Examination

During the consultation, we discuss your skin concerns and goals, then assess whether Celdiem (SKINPLUS) is suitable for you.
An individualized treatment plan is created based on your needs.

Procedure

If you are wearing makeup, it will be removed before the procedure.
Celdiem (SKINPLUS) is injected while sharing a clear image of the desired results with you throughout the treatment.

Aftercare

Makeup can be applied immediately after the procedure.
If desired, you may leave the clinic wearing makeup.
You may resume normal daily activities immediately after the procedure. Avoid strong pressure or vigorous massage on the treated areas for about one week.

Celdiem (SKINPLUS) – Frequently Asked Questions

What is Celdiem (SKINPLUS)?

Celdiem (SKINPLUS) is an injectable treatment based on human-derived ECM (extracellular matrix) components, including collagen and elastin, which support the skin’s structure.
It helps moisturize the skin, improve firmness and radiance, refine skin texture, and reduce fine wrinkles.

How is it different from hyaluronic acid injections?

Hyaluronic acid injections are primarily used to reshape or fill depressions in the skin.
Celdiem (SKINPLUS), on the other hand, is designed to improve skin quality and strengthen the skin’s foundational structure.

What skin concerns is it suitable for?

Celdiem (SKINPLUS) addresses a wide range of concerns, including:

  • Fine lines caused by dryness
  • Loss of firmness and radiance
  • Uneven skin texture
  • Visible pores

How often should the treatment be performed?

Some patients notice changes after a single session, while others require multiple sessions to see results.
We generally recommend a course of three sessions at one-month intervals.

Treatment frequency may vary depending on individual skin condition; please consult during your visit.

Is the treatment painful?

As with any injectable procedure, some discomfort may occur.
Celdiem (SKINPLUS) uses ultra-fine particles to minimize pain. Additionally, our clinic uses microcannulas to further reduce discomfort.

Can I apply makeup or wash my face immediately after treatment?

Generally, yes. However, this may vary depending on the treated area and condition.
Avoid rubbing or pressing the injection sites, regardless of makeup or washing.

When can I shower, bathe, or exercise?

Your condition will be assessed post-treatment, and guidance will be provided.
On the day of treatment, avoid intense exercise, alcohol, prolonged bathing, or sauna use.

Can Celdiem (SKINPLUS) be combined with other treatments?

In some cases, combining treatments may enhance results.
However, some procedures cannot be combined, or the order and timing may need adjustment.
Please discuss during consultation for personalized recommendations.