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The Author

DR. YOKO MAEDA

  • Board-Certified Specialist, American Academy of Anti-Aging Medicine (A4M)
  • Director, Japan Society of Aesthetic Internal Medicine

A graduate of Hiroshima University School of Medicine, Dr. Maeda is a U.S. and Japan–certified specialist in aesthetic and regenerative medicine, offering advanced treatments such as hormone therapy and peptide therapy.
She is known for her gentle, science-driven approach to natural beauty and continues to study the latest medical innovations with a passion for lifelong learning.

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Many people believe that “aging comes equally to everyone.” However, did you know that recent research suggests aging itself is a disease, and that with proper treatment, rejuvenation may actually be possible?

This idea gained attention in 2022, when the WHO added “age-related conditions” to the International Classification of Diseases, positioning aging as something that can and should be treated. The global concept of anti-aging is now undergoing a major shift.

Amid this trend, one term attracting increasing attention is “Longevity.” Let’s take a closer look at what this keyword really means.

What Does Longevity Mean?

Longevity comes from the Latin words longus (long) and aevum (age or lifetime), and is usually translated simply as “long life.”

In the field of anti-aging medicine, however, it refers more specifically to “living a long, healthy, and fulfilling life.”

In longevity medicine, “long life” does not mean only the period until physical death, known as life span. More important is health span—the length of time you can live independently with good physical and mental health.

In other words, the ideal is not just living longer, but maintaining a high quality of life (QOL) even as you age.

 

The Importance of Biological Age in Longevity

The first step in longevity is understanding your biological age.
There is an important difference between chronological age and biological age:

Difference between chronological and biological age

  • Chronological age: The number of years since birth
  • Biological age: An age estimated from the condition of your body, tissues, and cells

Chronological age increases every year, but biological age differs from person to person. That’s why people of the same age can look very different—some appear youthful, others much older.

If aging progresses faster, not only does appearance change, but physical function declines and the risk of age-related diseases increases. Biological age reflects this aging speed and is therefore a key indicator in longevity medicine.

While aging is a natural process, its speed varies greatly among individuals. And unlike chronological age, biological age can be slowed down—or even reversed—through lifestyle and medical interventions.

For example:

  • Taking longevity-supporting nutrients through diet or supplements
  • Maintaining regular sleep and exercise habits
  • Receiving medical treatments such as natural hormone replacement therapy or IV therapy in aesthetic internal medicine

 

Longevity Indicators: What You Can Learn from the Epigenetic Clock Test

Tests that measure your current level of aging are called “aging biomarkers.” These are groundbreaking tools in longevity medicine.

Aging treatments are long-term investments in your future self. Their effects may not be obvious immediately, but become meaningful 30 or 40 years later. Being able to predict future outcomes today greatly increases motivation—and allows you to change course if necessary.

Among various biomarkers, the most reliable at present is the Epigenetic Clock Test.

 

How the Epigenetic Clock Test Works

This test measures DNA methylation, which refers to chemical markers that switch genes on or off.

DNA is the blueprint of our body. When methyl groups attach to DNA, this process—called methylation—affects how genes function.

Recent studies have shown that DNA methylation patterns are closely linked to aging. For example, changes in methylation can alter protein function, leading to visible aging signs such as wrinkles or gray hair.

The Epigenetic Clock Test analyzes these methylation patterns in detail and estimates your biological age using just a blood sample.

 

For Aging Treatments Based on Biological Age, Visit BIANCA CLINIC

Around the world, interest in healthy aging is rapidly growing, and longevity is one of the key buzzwords for 2025.

Global media platform News Picks launched a project titled “HYPER HYPED LONGEVITY: the REPORT,” focusing on the forefront of anti-aging research. In Berlin, the large-scale event “Life Summit 2025” will also be held, dedicated entirely to longevity.

At BIANCA CLINIC, we are among the first in Japan to offer world-standard longevity medicine. Why not start by discovering your own biological age through the Epigenetic Clock Test?

If you are interested in longevity or have concerns about aging, feel free to consult us anytime.